Klonopin Vs Buspar

Difference Between Klonopin Vs Buspar

In the early 1960s, a new era came, which began the treatment of insomnia and anxiety. Anxiety may present as insomnia, headaches, recurring anxieties, musculoskeletal disorder, or gastrointestinal disorder.

Primary care doctors should be in a position to understand and treat specific anxiety disorders. Anxiety disorders or conditions include panic-free agoraphobia, physical and social phobias, obsessive-compulsive disorder, post-traumatic stress disorder, and acute stress disorder.

We are not here to promote any of the medications listed below, instead, we are here to provide you the right information about the drug you are using or are confused about which medication to buy, depending on your situation.

Introduction of Klonopin Vs Buspar:


Klonopin (Clonazepam) may minimize the seizure frequency in particular seizure disorders and may be used to treat panic disorder in the short term; however, it can cause symptoms of discontinuation, dependency, and withdrawal.

Klonopin (Clonazepam) is prescribed for Panic Disorder, Avoidance of Seizures, and Epilepsy.

This medication can also be prescribed off label for:

Periodic Limb Movement Disorder, Insomnia, Night Terrors, Migraine Avoidance, Hyperekplexia, Cluster-Tic Syndrome, Chronic Myofascial Pain, Burning Mouth Syndrome, Temporomandibular Joint Disorder, Anxiety, Bipolar Disorder, Borderline Personality Disorder, Obsessive-Compulsive Disorder, Sleep Deprivation, Restless Legs Syndrome.


Buspar (buspirone) can be used for anxiety treatment and is less likely to induce sedation than other anti-anxiety medications.

Buspar (buspirone) is prescribed for Panic disorder and anxiety. 

This medication can also be prescribed off label for the Sexual Dysfunction-SSRI Caused and Borderline Personality Disorder.

Disease Interactions


  • Acute alcohol intoxication
  • Closed-angle glaucoma
  • Drug dependence
  • Respiratory depression
  • Seizures
  • Renal/liver disease
  • Suicidal tendency
  • Depression
  • Obesity
  • Paradoxical reactions


  • Depression
  • Renal/liver disease
  • Glaucoma
  • Liver disease
  • Drug dependence

Drug Interactions

With Buspar:

Buspar (buspirone) is known to interact with MAOIs, trazodone, nefazodone, warfarin, itraconazole, erythromycin, and rifampin.

With Klonopin:

Klonopin (Clonazepam) can interact with cold or allergy medication, narcotic pain medicine, sleeping pills, muscle relaxers, depression or anxiety medicine, antimicrobials, antibiotics, antidepressants, and barbiturates.

To treat psychological conditions, Klonopin can also interact with propantheline, MAO inhibitors, or medicines.

Do not stop using Klonopin without talking to your doctor first, even though you are feeling good. If you stop using Klonopin unexpectedly, you can experience increased seizures or painful withdrawal symptoms.

How to take Klonopin and Buspar


Suddenly stopping Klonopin can cause spontaneous seizures.

Klonopin (Clonazepam) can cause abuse and addiction. And don’t stop unexpectedly taking Klonopin. Suddenly stopping Klonopin can trigger seizures that don’t stop, hear, or see things that aren’t there (hallucinations), trembling, and cramps in the stomach and muscle.

Speak to your healthcare provider about halting Klonopin slowly to prevent signs of withdrawal.


Buspar (buspirone) is to be taken regularly at the same time. BuSpar can be taken with or even without food, as you wish. Though it is suggested to take with food especially if you have the problem of nausea.

Side Effects of Klonopin and Buspar


  • Respiratory depression
  • Fainting
  • Enlarged liver
  • Withdrawal symptoms (if stopped suddenly)
  • Increased heart rate
  • Low blood pressure
  • Blood disorders


  • Diarrhea
  • Excitement
  • Weakness
  • Hostility
  • Skin rash
  • Tremors

Dosage of Klonopin and Buspar


  • The dose of Klonopin is tailored to the patient’s needs. 
  • Klonopin dosage is adjusted and decided as per the needs of the patient. However, the initial dose is decided as 1.5 mg daily, divided into 3 equal doses, for seizures in adults. 
  • Until seizures are controlled properly, the dosage may increase from 0.5 mg per day to 1 mg for the next 3 days.  
  • The maximum dose of Klonopin is 20 mg daily, while the initial dose for panic disorders is 0.25 mg twice daily. 
  • After 3 days the dose may be increased to 1 mg daily.


  • The normal starting dose of Buspar for adults is 10-15 mg given daily in 2 or 3 doses.
  • Until an appropriate dose is found, the dose may be increased by 5 mg every 2 to 4 days.
  • The maximum adult dosage is 60 mg per day but most patients are known to respond to 15-30 mg per day.
  • While food increases the amount of buspirone that is absorbed, it’s not clear how powerful this effect is.
  • Buspar can be consumed with or without food, but preferably regularly.

Upsides of Klonopin and Buspar

Upsides of Klonopin:

  • More individuals who took Klonopin (clonazepam) were liberated from any panic attacks, compared with the individuals who didn’t take Klonopin (clonazepam). 
  • Klonopin (clonazepam) works rapidly, within an hour. 
  • Klonopin (clonazepam) keeps going on for a longer time and has less serious withdrawal manifestations compared with other similar meds.
  • However, Klonopin (clonazepam) can be utilized along with antidepressants to oversee panic disorder. 

Upsides of Buspar:

  • Doesn’t cause as much physical reliance or withdrawal side effects as different meds that are utilized for anxiety. 
  • Accessible as a generic, that means it is less expensive. 
  • You can split the tablets for simple dose changes. 
  • This medication doesn’t cause as much drowsiness as different prescriptions that are taken for anxiety problems.

Downsides of Klonopin and Buspar

Every coin has two sides, a head, and a tail. The same is the case with all the meds. We have advantages as well as disadvantages. We have benefits as well as risks. All you need to see is that the benefits exceed the risks. 

Downsides of Klonopin:

  • Klonopin (clonazepam) is known to cause memory problems, tiredness, unsteadiness, confusion, dizziness, and disarray. 
  • Klonopin (clonazepam) can be propensity framing or habit-forming, so isn’t commonly utilized for long haul treatment. 
  • To establish a similar seizure control after some time, higher dosages of Klonopin (clonazepam) may be required.

Downsides of Buspar:

    • Since Buspar can take up to about a month to completely work, it is not recommended for fast relief of anxiety symptoms.
    • This medication is not as effective for panic disorders or short-term anxiety conditions.
    • A few people find that taking Buspar for a long term loses effectiveness in their body.
    • To avail the most benefit from this medication, take this twice a day.

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